Endocrine Abstracts

Emerging evidence indicates that the cellular machinery controlling the splicing process (spliceosome) is altered in several tumour types, leading to oncogenic splicing events associated with tumour progression and aggressiveness. However, whether this molecular phenomenon also occurs in thyroid cancer has not been yet explored. Therefore, our main aim was to explore the potential dysregulation of the expression of relevant spliceosome components and splicing factors in clinic...

Objective: Flash glucose monitoring (FGM) allows non-invasive glucose level assessment. Our objective was to describe the characteristics of these patients and their glycemic control expressed as HbA1c and times in range. Methods and patientsObservational longitudinal clinical study between January 2021 and December 2021 in patients with DM1 between 14 and 18 years. Results 95 patients included. Mean age: 16.64 ± 1.25 years, with a mean DM evolution time of 6.46 ± 3....

Objective: Adrenal venous sampling (AVS) is a reliable procedure to differentiate if in patients with primary aldosteronism (PA) aldosterone production is unilateral or bilateral and guide treatment of these patients. Our objective was to describe their characteristics and the outcomes of the AVS.Methods and patients: Observational longitudinal clinical study between July 2020 and November 2022 in patients who underwent AVS in our Hospital.<p class="...

Background: 3q29 microduplication syndrome is a very uncommon genetic disorder with fewer than 40 cases reported, although the wide and heterogenous clinical features make this syndrome hard to diagnose. This syndrome is clinically milder than the 3q29 microdeletion syndrome, which contributes to the high rate of underdiagnosed cases that may exist. Patients affected with this syndrome have a complex phenotype, with non-specific clinical features such as autism spectrum disord...

Introduction: Low testosterone serum levels are associated with increased mortality in non-diabetic males. However, knowledge about the association between male hypogonadism and mortality among type 2 diabetic (T2DM) men is limited due to short follow-up periods in the few existing studies.Objective: To assess the association between hypogonadism and mortality in diabetic men.Material and methods: 263 unselected men with T2DM (mean...

Introduction: Graves’ and Hashimoto’s diseases are considered two extremes of the same autoimmune thyroid disease. Spontaneous conversion from hypothyroidism to hyperthyroidism is uncommon. On the other hand, Graves’ disease typically improves during pregnancy and worsens after delivery. We describe a patient with an unusual course of thyroid disease during pregnancy.Case report: An 33-year-old woman, with a two-year history of hypothyroid...

Introduction: Controversy exists regarding type 2 diabetes (T2D) remission rates after bariatric surgery (BS) due to heterogeneity in its definition and patients’ baseline features. We evaluate T2D remission using recent criteria, according to preoperative characteristics and insulin use.Materials and methods: Retrospective study from a cohort of 657 BS performed in a single centre (2006–2011) of which 141 (57.4% women) had T2D. Evaluation of a...

Introduction: Remission of type 2 diabetes (T2D) is a yearned outcome after bariatric surgery (BS). Attention to individuals who do not strictly fulfil remission criteria has been frequently left behind. The aim of this study was to evaluate metabolic control status in patients considered as diabetes ‘non-remitters’.Materials and methods: Retrospective study of 125 patients (59.2% women) with preoperative diagnosis of T2D who underwent BS in a ...

Purposes: To report the prevalence of obesity, metabolic syndrome (MS) and its related components among adolescents living in the city of Almería (south of Spain). To examine the distribution of HOMA-IR (homeostasis model assessment of insulin resistance).Methods: A total of 373 subjects attending secundary school (aged 12–17 years) participated in a community-based cross-sectional survey. IOTF (International Obesity Task Force) criteria were u...

Backround and objectives: Heart failure (HF) has a rising incidence and is one of the most prevalent diseases worldwide. The number of patients with type 2 diabetes (T2DM) with heart failure is very high. Serum NT-proBNP and systolic ejection fraction correlate with the severity and prognosis of this condition. The nutritional evaluation of patients with HF, who usually have normal weight, overweight or obesity, has acquired a novel approach due to the incorporation of novel t...